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pentobarbital will decrease the level or effect of darunavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.Check Carefully (2)pentobarbital will lessen the extent or effect of buprenorphine, long-acting injection by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Sufferers